l0stboy Posted March 15, 2012 Report Share Posted March 15, 2012 (edited) Does anyone know what would be a good method of titration? I'm leaning on the side of titration with HCl and NaOH since that's what our instructor is insisting we use. Currently, if I can't get a better idea, I'll be sticking to testing antacids by placing the prescribed dosage in a known molarity of HCl. Edited March 15, 2012 by l0stboy Reply Link to post Share on other sites More sharing options...
Sandwich Posted March 15, 2012 Report Share Posted March 15, 2012 Sounds decent to me. As to method of titration, traditionally you want some pH measure (e.g. indicator) and a burette, then to drop the NaOH down into the acid until you hit neutral, then figure out how many moles of NaOH it took.Any strong acid/base pairing will do, tbh, if you want to mix it up a little bit. Reply Link to post Share on other sites More sharing options...
Drake Glau Posted March 15, 2012 Report Share Posted March 15, 2012 You can use a strong acid/strong base, a weak acid/strong base, or a strong acid/weak base. Each combination will need a different indicator though. The strong acid/strong base one you can just use phenolphthalein (probably spelled that wrong). For the other two you can just look up an indicator with an equivalence point around 3-4 (strong acid/weak base) or 9-10 (strong base/weak acid). Of course I'd just stick to the strong acid/strong base choice. It's much simpler 1 Reply Link to post Share on other sites More sharing options...
l0stboy Posted March 15, 2012 Author Report Share Posted March 15, 2012 (edited) Sounds good. I just wanted to make sure that I was in the right direction. However, if I dorp an antacid in the solution, would the color indicator still work right? My lab partner and I decided to test which dosage of different antacids proves to be the most effective. Edited March 16, 2012 by l0stboy Reply Link to post Share on other sites More sharing options...
Drake Glau Posted March 16, 2012 Report Share Posted March 16, 2012 You will be putting the tablet in a solution of HCl by itself. After it is done reacting you can add the indicator for the titration. The indicator is only to help you during the titration 1 Reply Link to post Share on other sites More sharing options...
l0stboy Posted March 17, 2012 Author Report Share Posted March 17, 2012 What I ended up doing is putting the antacid, which was actually a milky liquid. My instructor told us it's better to put the have measured antacid with the universal indicator and then slowly add the HCl. Initially when the indicator was added, the antacid showed to have a pH of 8. As the HCl was added it progressive became paler. It was really hard to see a good color change since the antacid was milky. We measured how much it took to get to neutral per 5mL. I think I might do it again until I see a better color change that is more apparent like pink because when I did it until it was neutral, it was incredibly hard to see the color change, but it was there. Reply Link to post Share on other sites More sharing options...
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